Predictors of recovery of ovarian function during aromatase inhibitor therapy

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Predictors of recovery of ovarian function during aromatase inhibitor therapy.

BACKGROUND Aromatase inhibitors (AIs) may cause a rise in estrogen levels due to ovarian function recovery in women with clinical chemotherapy-induced ovarian failure (CIOF). We carried out a prospective registry trial to identify predictors of ovarian function recovery during AI therapy. PATIENTS AND METHODS Women with hormone receptor (HR)-positive breast cancer who remained amenorrheic and...

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Effects of the non-steroidal aromatase inhibitor letrozole on ovarian function in cattle were determined. The hypothesis that letrozole would arrest growth of the dominant follicle, resulting in emergence of a new follicular wave at a predictable post-treatment interval, was tested. Heifers were assigned randomly to four groups 4 days after follicular ablation (~2½ days after wave emergence) an...

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ژورنال

عنوان ژورنال: Annals of Oncology

سال: 2013

ISSN: 0923-7534

DOI: 10.1093/annonc/mdt149